P38 MAPK AND JNK ANTAGONISTICALLY CONTROL SENESCENCE AND CYTOPLASMIC P16INK4A EXPRESSION IN DOXORUBICIN-TREATED ENDOTHELIAL PROGENITOR CELLS.

p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells.

Patients treated with low-dose anthracyclines often show late onset cardiotoxicity.Recent studies suggest that this form of cardiotoxicity is the result of a progenitor cell disease.In this study we demonstrate that Cord Blood Endothelial Progenitor Cells (EPCs) exposed to low, sub-apoptotic doses of doxorubicin show a senescence phenotype characte

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Soil moisture data for the validation of permafrost models using direct and indirect measurement approaches at three alpine sites

In regions affected by seasonal and permanently frozen conditions soil moisture influences the thermal regime of the ground as well as its 621 ice content, which is one of the main factors controlling the sensitivity of mountain permafrost to climate changes.In this study, several well established soil moisture monitoring techniques were combined w

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