p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells.
Patients treated with low-dose anthracyclines often show late onset cardiotoxicity.Recent studies suggest that this form of cardiotoxicity is the result of a progenitor cell disease.In this study we demonstrate that Cord Blood Endothelial Progenitor Cells (EPCs) exposed to low, sub-apoptotic doses of doxorubicin show a senescence phenotype characte